Beta-2 microglobulin removal with postdilution online hemodiafiltration - comparison of three different dialysis membranes

نویسندگان

چکیده

Introduction. Accumulation of middle molecular weight uremic toxins causes various complications in chronic hemodialysis (HD) patients. Postdilution online hemodiafiltration (OL-HDF) efficiently removes these molecules. This study aimed to assess the effectiveness three different dialysis membranes removing ?2- microglobulin (?2m) within a single session postdilution OL-HDF. Method. A prospective single-center was carried out 30 patients (23 males and seven females, average age 54.87 ? 11.66 years, time on 4.95 5.4 years) maintenance HD. Each patient followed for consecutive weeks OL-HDF with dialyzers: DiacapPro 19H, FX CorDiax 800, Elisio 21H, randomly switched weekly. The reduction ratios (RR) ?2m albumin were compared individually. results analyzed Kolmogorov?Smirnov test, ANOVA, Kruskal?Wallis test. Results. convective volume all 21.38 2.97 L/session. ?2-m RR 70.86 6.87%, 74.69 6.51%, 70.04 9.37% Diacap Pro 800 21H membrane, respectively (p = 0.054). Albumin 6.20 2.12% 19H 6.01 2.97% 6.46 2.91% membrane 0.812). loss < 4 g/dialysis treatment membranes. Conclusion. All investigated effectively remove tolerable loss. highest determined but no statistically significant difference.

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ژورنال

عنوان ژورنال: Srpski Arhiv Za Celokupno Lekarstvo

سال: 2021

ISSN: ['0370-8179', '2406-0895']

DOI: https://doi.org/10.2298/sarh210329048n